In a follow-up to a previous blog post we did in our series of “living with” here’s another great video that we found online about living with a traumatic brain injury.
Micah Jones was hit by a car driven by a drunk police officer as she crossed the street to get a taxi while interning for a record publisher in Nashville. Micah survived and suffered a severe traumatic brain injury (TBI). Since her injury Micah founded BrainSong, The Micah Jones Foundation, a non profit for women with brain injuries – read more at www.BrainSong.org.
Recently, Micah was instrumental in getting July 9 named Traumatic Brain Injury Awareness Day in Ohio.This is her story.
Opportunities abound of having to play “nurse” to heal a wound. A graze gardening, cut with a kitchen knife, scrape by falling bike, a cut in the finger with pruning shears …: a wound, however small, always deserves greater attention and must be treated in as fast as we can. A simple sore can turn the big catastrophe. All wounds must be disinfected to prevent the risk of infection. Coat the wound saliva – especially if it is not that of the injured person – is cons-indicated.
Superficial or deep wound?
The pain is not a determining element: a cut with a sheet of paper between two fingers can be more painful than a deep wound in the arm. It is the same for the bleeding: in some places, the body bleeds more abundantly than others. This does not mean that the wound is deeper.
The superficial wound
For superficial wound means a simple skin abrasion, a scratch, a slight cut or scratch. It will surface when it has not been caused by a blunt object and is little scope: the affected area will be less than the size of the palm of an adult hand. You can easily curb the blood and treat the injury. Do not forget though that the same superficial wound can lead to infection.
The wound (more) deep
Disinfecting the wound, it may be deeper than it seems, especially if clean cut with a sharp object. If the wound edges suggest an injury 3-4 mm depth will reduce the bleeding by applying sterile gauze or by signing, after disinfection, adhesive strips Steri-strip type to bring the wound edges . The next step is to protect the wound with a bandage. These “strips” will remain in place for at least five days.
Faced with a deeper wound and / or larger, the doctor will practice sutures or staples pose. In severe cases, surgery will be necessary.
How to disinfect a wound?
You proceed on your own or you come to the aid of a wounded, first and foremost, always wash hands thoroughly, rubbing each finger well with soap.
• In the presence of foreign bodies embedded like gravel, earth, a thorn, twigs, grass, remove them gently with tweezers passed previously in alcohol; or when the flame of a lighter or a match.
• Rinse the wound with clean, warm water.
• Then clean the edges with soap (preferably unscented Marseille) or with a cleaning solution such as the cetavlon. Use especially not hydrophilic or cotton wadding, leaving the fibers to the wound.
• Do not rub the wound but dab it with a disinfectant or antiseptic neutral, colorless preference.
• Avoid alcohol, whether denatured or not. Indeed, alcohol causes not only a sharp pain in the application, but also the risk of damaging the skin cells and thus slow the healing process.
• Avoid – at first instance – the colored disinfectants (eosin, formerly Mercurochrome, iso-betadine, etc.) because their staining might mask any foreign body. You can use them later for their drying and healing power.
A superficial wound should be buffered with sterile gauze, knowing that you should never rub, at the risk of aggravating the injury (not to mention the inconvenience pain).
If the wound is bleeding a lot, it will be necessary to conduct a compression using sterile cotton or cloth (clean) to stem the bleeding.
If after ten to fifteen minutes, the bleeding continues, or if the blood flows through jets, emergency management, while maintaining compression.
The application of hydrogen peroxide provides a coagulating effect.
How to clean the wound?
The wound is cleaned from the center to the edges, tapping with sterile gauze or a clean cloth, and far beyond with disinfectant. It is better to put on too much than not enough, and thus enable radically remove dirt.
In the reverse order, ie the periphery of the wound toward the center, this could fold infectious agents.
And if a bleeding wound must obviously be treated (especially quickly and forcefully that the stream is important), the blood flow is not necessarily a bad thing, since it serves to remove some impurities.
When will it urgent?
• Any major wound of the hand or fingers, even if the bleeding seems under control, requires the advice of a doctor.
• A wound to the chest, abdomen, to the eye, to the temple or touching an articulation requires prompt medical attention.
• If you cut, wrap in a clean cloth, which will be placed in a plastic bag, in turn deposited in a container with ice. Caution: Never put the severed part in direct contact with the ice.
• It is prudent to ensure that vaccination against tetanus is up to date. Otherwise, a point will be necessary. Tetanus vaccine must be renewed every ten years, but the doctor may nevertheless decide preventive reminder, even if the injury occurs less than ten years after the last booster.
• Diabetics and patients with circulatory problems or blood clotting consult a doctor in case of wound itself (relatively) shallow.
How to protect a wound?
Protect the wound with a bandage if it may be exposed to dirt, acidity, chemical products or rubbing against clothing. Otherwise, let the injury heal in the open air, however, knowing that contrary to popular belief, gall heal faster in moisture with a bandage.
When will form a crust, do not scratch: it protects the wound against contamination.
Unless medically indicated, the dressing should not be repeated too often, as this may slow healing (some types dressings also allow to speed).
If the edges of the wound are jagged irregular or if you develop redness and swelling around the wound, if a foreign body (splinter, earth, sand) remains embedded in the wound, if a thick liquid drains off or if there is presence of pus, medical advice is required.
Some important tips here, please read and digest just in case your child ever suffers with a serious accident or injury to their head.
You must seek medical emergency assistance if your child:
conscious, but if you fear a neck injury;
suffers from nausea or vomiting;
has blood or clear fluid coming out of his nose and his ears;
presence of severe headaches that last more than an hour;
has an irregular or abnormal breathing;
suffers from dizziness and vertigo;
is sleepy or lose consciousness;
has difficulty moving or fewer sensations;
has blurred vision;
suffers from convulsions (involuntary contractions causing violent muscle movements of a body part or the whole body).
If in doubt, do not hesitate to contact the emergency services, or call a local doctor for immediate advice. Please do not try and diagnose on Youtube as some people have been known to do.
If your child does not seem to have fracture a fracture after the incident then you must:
Apply a bandage on the wound and apply pressure to stop the bleeding.
Secure the dressing with a bandage.
If your child is hit, but not bleeding, apply pressure on the wound, and to reduce swelling, apply a cold compress or ice where it hurts.
If you fear that they have an injury to the head or neck:
Secure the head and neck, and hold it in the position in which you found it.
If he wears a helmet, do not remove it.
Call the emergency services.
If bleeding continues then apply a compress on the wound, applying light pressure, unless blood or other fluid flowing from his nose and his ears. Pansez slightly affected area with a clean cloth or gauze.
A fall of 15 cm (6 in) onto a hard surface is sufficient to cause significant head injuries. See a doctor if your child has head injuries, although the injury does not seem serious.
How to prevent accidents?
Use safety gates to prevent your child falls down stairs.
Make sure he puts his seatbelt in a vehicle.
Stay cautious near a body of water: teach your child to enter feet first, and make sure the water is deep enough before he plunges into it.
Army and military veterans who have suffered from a traumatic brain injury talk about how they are coping, plus some of their own personal experiences in this video.
Some of the veterans in the video describe how they realised they had the signs of TBI (traumatic brain injury) and what effect it has had on their friends and families who have been their to support them in their recovery and recuperation. By reaching out for help, they were able to overcome these obstacles and live better lives.
The main purpose of this server is to allow individual and comparative analysis of protein interactions. We have developed a structural classification of protein binding regions at family level based on the structural classification of proteins, SCOP. The user can easily navigate through the classification till the family of interest, where all the interacting information is collected.
Three hierarchical interaction levels are defined: family, binding region and interface levels. The binding regions are defined as distinctive surface regions of a protein family used to recognize other molecules. The interfaces distinguish the different partners or ligands that a specific region can recognize. Ligands include proteins, peptides, nucleic acids and saccharides.
Explore the different regions that the protein family “Heat-shock transcription factor” uses to recognize other molecules
Type the name “Heat-shock transcription factor” in the search box. Two binding regions are shown: BR_1890 and BR_1891, where a different interacting pattern is shown in the alignment
Click to visualize the differences in the binding surfaces and the information about the partners in the control panel.
Click to download all pdb_chains complexes with the same binding region
Click to predicted binding regions to get alternatives observed in proteins structurally similar to “Heat-shock transcription factor”
Identify a binding region that can recognize both, a protein and a DNA molecule
Select in the search options for DNA “and” protein to filter the SCOP hierarchy for these families
Navigate through the hierarchy, for instance: all alpha proteins » DNA/RNA binding 3-helical bundle » “Winged helix” DNA binding domain » Heat-shock transcription factor (TF) » BR_1892
Interface IF_1893 corresponds to a TF homo-dimerization, whereas IF_1894 the TF interacts to DNA through the same region as it can be observed in both, the alignment pattern and the 3D viewer. Select any IF ID to visualize all interacting information for comparative analysis.
Identify all interacting information from a protein complex:
Type a pdb file (1omw), all interaction between molecule pairs are shown, sorted out by family and binding region
Select the domain binding region of interest (PH domain: BR_22689), you are redirected to the interface page, where it shows the different ligands that this region can recognize: Regulator of G protein signal, PH domain and BAR domain.
Select the interface with RGS (IF_22690), all PH domains interacting to RGS are shown with the interaction pattern colored by water mediation or chemical type. Upon clicking a residue in the alignment it is highlighted in the 3D viewer and detailed interacting information is shown in the control frame.
References to SCOWLP:
Teyra J, Samsonov S, Schreiber S, Pisabarro MT. SCOWLP update: 3D classification of protein-protein, -peptide, -saccharide and -nucleic acid interactions, and structure-based binding inferences across folds. BMC Bioinformatics, 2011 Oct 13;12:398
Teyra J, Paszkowski-Rogacz M, Anders G, Pisabarro MT. SCOWLP classification: Structural comparison and analysis of protein binding regions. BMC Bioinformatics, 2008 Jan 8;9:9.
Teyra J, Doms A, Schroeder M, Pisabarro MT. SCOWLP: a web-based database for detailed characterization and visualization of protein interfaces. BMC Bioinformatics. 2006 Mar 2;7(1):104
References to SCOWLP usage:
Samsonov S, Teyra J, Anders G, Pisabarro MT. Analysis of the impact of solvent on contacts prediction in proteins. BMC Structural Biology, 2009 Apr 15;9:22.
Samsonov S, Teyra J, Pisabarro MT: A molecular dynamics approach to study the importance of solvent in protein interactions. Proteins. 2008 Nov 1;73(2):515-25.
Teyra J, Pisabarro MT. Characterization of interfacial solvent in protein complexes and contribution of wet spots to the interface description. Proteins, 2007 Jun 1;67(4):1087-95.